User profiles for "author:Francesca Duncan"
Francesca DuncanAssistant Professor, Northwestern University Verified email at northwestern.edu Cited by 3673 |
[HTML][HTML] A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice
Emerging additive manufacturing techniques enable investigation of the effects of pore
geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to …
geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to …
[PDF][PDF] Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes
Aneuploidy arising early in development is the leading genetic cause of birth defects and
developmental disabilities in humans. Most errors in chromosome number originate from the …
developmental disabilities in humans. Most errors in chromosome number originate from the …
In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables
LE Simon, TR Kumar, FE Duncan - Biology of Reproduction, 2020 - academic.oup.com
Folliculogenesis is a complex process that requires integration of autocrine, paracrine, and
endocrine factors together with tightly regulated interactions between granulosa cells and …
endocrine factors together with tightly regulated interactions between granulosa cells and …
The sweet side of the cell cycle
Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for
normal organismal development. The mammalian cell cycle is tightly regulated by different …
normal organismal development. The mammalian cell cycle is tightly regulated by different …
Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks
Fertilization of a mammalian egg initiates a series of 'zinc sparks' that are necessary to
induce the egg-to-embryo transition. Despite the importance of these zinc-efflux events little …
induce the egg-to-embryo transition. Despite the importance of these zinc-efflux events little …
Reproductive age-associated fibrosis in the stroma of the mammalian ovary
SM Briley, S Jasti, JM McCracken, JE Hornick… - …, 2016 - rep.bioscientifica.com
Under normal physiological conditions, tissue remodeling in response to injury leads to
tissue regeneration without permanent damage. However, if homeostasis between synthesis …
tissue regeneration without permanent damage. However, if homeostasis between synthesis …
Chromosome cohesion decreases in human eggs with advanced maternal age
Aneuploidy in human eggs increases with maternal age and can result in infertility,
miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however …
miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however …
The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond
BM Smith, FE Duncan, L Ataman, K Smith… - Future …, 2018 - Future Medicine
Once unimaginable, fertility management is now a nationally established part of cancer care
in institutions, from academic centers to community hospitals to private practices. Over the …
in institutions, from academic centers to community hospitals to private practices. Over the …
mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy
KN Goldman, D Chenette, R Arju… - Proceedings of the …, 2017 - National Acad Sciences
The ovary contains oocytes within immature (primordial) follicles that are fixed in number at
birth. Activation of follicles within this fixed pool causes an irreversible decline in …
birth. Activation of follicles within this fixed pool causes an irreversible decline in …
Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue
Purpose In vitro follicle growth (IVFG) is an investigational fertility preservation technique in
which immature follicles are grown in culture to produce mature eggs that can ultimately be …
which immature follicles are grown in culture to produce mature eggs that can ultimately be …