User profiles for "author:Francesca Duncan"

Francesca Duncan

Assistant Professor, Northwestern University
Verified email at northwestern.edu
Cited by 3673

[HTML][HTML] A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice

MM Laronda, AL Rutz, S Xiao, KA Whelan… - Nature …, 2017 - nature.com
Emerging additive manufacturing techniques enable investigation of the effects of pore
geometry on cell behavior and function. Here, we 3D print microporous hydrogel scaffolds to …

[PDF][PDF] Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes

T Chiang, FE Duncan, K Schindler, RM Schultz… - Current Biology, 2010 - cell.com
Aneuploidy arising early in development is the leading genetic cause of birth defects and
developmental disabilities in humans. Most errors in chromosome number originate from the …

In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables

LE Simon, TR Kumar, FE Duncan - Biology of Reproduction, 2020 - academic.oup.com
Folliculogenesis is a complex process that requires integration of autocrine, paracrine, and
endocrine factors together with tightly regulated interactions between granulosa cells and …

The sweet side of the cell cycle

EP Tan, FE Duncan, C Slawson - Biochemical Society …, 2017 - portlandpress.com
Cell division (mitosis) and gamete production (meiosis) are fundamental requirements for
normal organismal development. The mammalian cell cycle is tightly regulated by different …

Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks

EL Que, R Bleher, FE Duncan, BY Kong, SC Gleber… - Nature …, 2015 - nature.com
Fertilization of a mammalian egg initiates a series of 'zinc sparks' that are necessary to
induce the egg-to-embryo transition. Despite the importance of these zinc-efflux events little …

Reproductive age-associated fibrosis in the stroma of the mammalian ovary

SM Briley, S Jasti, JM McCracken, JE Hornick… - …, 2016 - rep.bioscientifica.com
Under normal physiological conditions, tissue remodeling in response to injury leads to
tissue regeneration without permanent damage. However, if homeostasis between synthesis …

Chromosome cohesion decreases in human eggs with advanced maternal age

FE Duncan, JE Hornick, MA Lampson, RM Schultz… - Aging cell, 2012 - Wiley Online Library
Aneuploidy in human eggs increases with maternal age and can result in infertility,
miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however …

The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond

BM Smith, FE Duncan, L Ataman, K Smith… - Future …, 2018 - Future Medicine
Once unimaginable, fertility management is now a nationally established part of cancer care
in institutions, from academic centers to community hospitals to private practices. Over the …

mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

KN Goldman, D Chenette, R Arju… - Proceedings of the …, 2017 - National Acad Sciences
The ovary contains oocytes within immature (primordial) follicles that are fixed in number at
birth. Activation of follicles within this fixed pool causes an irreversible decline in …

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

MM Laronda, FE Duncan, JE Hornick, M Xu… - Journal of assisted …, 2014 - Springer
Purpose In vitro follicle growth (IVFG) is an investigational fertility preservation technique in
which immature follicles are grown in culture to produce mature eggs that can ultimately be …