▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA).
It is now clear that these cytokines play a fundamental role in the processes that cause …

This article surveys worldwide medical, ethical, and legal trends and initiatives related to the
concept of pain management as a human right. This concept recently gained momentum …

The effect of tumour necrosis factor (TNFα) antibodies on synovial cell interleukin-1 (IL-1)
production was investigated in 7 patients with rheumatoid arthritis and in 7 with …

Objective. To evaluate the safety and efficacy of a chimeric monoclonal antibody to tumor
necrosis factor α (TNFα) in the treatment of patients with rheumatoid arthritis (RA). Methods …

Although there have been major advances in the treatment of rheumatoid arthritis with the
advent of biological agents, the mechanisms that drive cytokine production and sustain …

Patients with advanced chronic kidney disease (CKD) have a high burden of physical and
psychosocial symptoms, poor outcomes, and high costs of care. Current paradigms of care …

The presence and the role of interleukin 10 (IL-10), a potent cytokine synthesis inhibitory
factor and antiinflammatory cytokine, were investigated in rheumatoid arthritis (RA). The …

This review seeks to describe data which support the concept that TNFα has a pivotal role in
the pathogenesis of RA. There is now compelling evidence from in vitro studies and in …

Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), in addition to being a growth
factor for granulocytes and macrophages, is an activator of cells of the monocyte …