ReviewThe circulatory systemic environment as a modulator of neurogenesis and brain aging
Section snippets
Take-home messages
- •
The aging circulatory systemic environment impairs neurogenesis and cognitive functions.
- •
Increased levels of immune signaling molecules comprise the aging systemic environment.
- •
Increasing systemic chemokine levels mimic the effects of aging on neurogenesis and cognitive functions.
- •
Rejuvenating factors exist in the young systemic environment.
References (40)
- et al.
For the long run: maintaining germinal niches in the adult brain
Neuron
(2004) Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
Cell
(2012)A specialized vascular niche for adult neural stem cells
Cell Stem Cell
(2008)- et al.
Immune activation in brain aging and neurodegeneration: too much or too little?
Neuron
(2009) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
Cell Stem Cell
(2010)FoxO3 regulates neural stem cell homeostasis
Cell Stem Cell
(2009)FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
Cell Stem Cell
(2009)Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
Neuroscience
(2001)- et al.
Immune influence on adult neural stem cell regulation and function
Neuron
(2009) - et al.
Adult hippocampal neurogenesis and aging
Eur Arch Psychiatry Clin Neurosci
(2007)
Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia
Proc Natl Acad Sci U S A
Neurogenesis in the adult human hippocampus
Nat Med
Hippocampal neurogenesis in adult Old World primates
Proc Natl Acad Sci U S A
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
Proc Natl Acad Sci U S A
Mammalian neural stem cells
Science (New York, N.Y.)
Suppression of adult neurogenesis impairs olfactory learning and memory in an adult insect
J Neurosci
Spatial learning depends on both the addition and removal of new hippocampal neurons
PLoS Biol
Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells
Science
Vascular niche for adult hippocampal neurogenesis
J Comp Neurol
Stem cells, ageing and the quest for immortality
Nature
Cited by (48)
Ovarian rescue in women with premature ovarian insufficiency: facts and fiction
2023, Reproductive BioMedicine OnlineAutologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders
2018, Fertility and SterilityRetinoic Acid Is Required for Neural Stem and Progenitor Cell Proliferation in the Adult Hippocampus
2018, Stem Cell ReportsCitation Excerpt :Cell extrinsic factors in the SGZ microenvironment critically regulate NSPC behavior and are produced both locally and from outside the niche. Cell extrinsic factors contributing to the NSPC microenvironment can be systemic factors delivered via blood vessels (Villeda et al., 2011, 2014; Villeda and Wyss-Coray, 2013) or cerebrospinal fluid factors that cross into the subventricular zone (SVZ) niche at the ventricular surface (Silva-Vargas et al., 2016). Factors delivered at these niche interfaces influence neural stem cell (NSC) maintenance and neurogenesis.
Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions
2018, Ageing Research ReviewsAging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis
2018, Free Radical Biology and MedicineCitation Excerpt :These processes of “senescence-induced senescence” and “inflammation-induced inflammation” appear to be important mechanisms in aging and the induction and progression of neurodegeneration and other age-associated diseases. Strong evidence in favor of the propagation hypothesis of an aging phenotype is provided by heterochronic parabiosis experiments in rodents that have shown that molecules that induce brain aging in old mice can be passed to young mice via transfusion to incur accelerated aging/degenerative effects; and molecules capable of maintaining brain functions of young mice can be passed to older mice via blood transfusion, so as to incur cerebral “rejuvenating” effects [155–157]. Similar “rejuvenating” effects can be produced in vitro using media from cultured human satellite muscle stem cells [158].
Impact of aging immune system on neurodegeneration and potential immunotherapies
2017, Progress in Neurobiology