PT  - JOURNAL ARTICLE
AU  - Rosengarten, Marsha
TI  - Perplexity as a provocation: revisiting the role of metaphor as a ‘place holder’ for the potential of COVID-19 antibodies
AID  - 10.1136/medhum-2021-012343
DP  - 2022 May 30
TA  - Medical Humanities
PG  - medhum-2021-012343
4099  - http://mh.bmj.com/content/early/2022/05/29/medhum-2021-012343.short
4100  - http://mh.bmj.com/content/early/2022/05/29/medhum-2021-012343.full
AB  - This article revisits long-standing critiques of the role of metaphor in immunological discourse. Drawing on Alfred North Whitehead’s speculative philosophy of organism, I focus on the use of metaphor to explain the process by which COVID-19 vaccine research is able to generate protective antibodies, the challenge of autoimmune disease and dengue fever antibodies. I suggest that metaphors are provoked by the perplexity that arises from presupposing that distinct morphological substances are the first order of reality. I conclude that rather than seeing metaphors as typically skewing conceptions of the body, as has been previously argued, those of memory, recognition and misrecognition may be instructive of a body in transition. Indeed, a process of transition that shows degrees of creativity. When gesturing towards the processual nature of infection and immunity, metaphors invite new modes of shared thinking across the disciplinary divide.Data sharing is not applicable as no data sets were generated and/or analysed for this study.