RT Journal Article SR Electronic T1 Animal research nexus: a new approach to the connections between science, health and animal welfare JF Medical Humanities JO J Med Humanit FD BMJ Publishing Group Ltd and Institute of Medical Ethics SP 499 OP 511 DO 10.1136/medhum-2019-011778 VO 46 IS 4 A1 Gail Davies A1 Richard Gorman A1 Beth Greenhough A1 Pru Hobson-West A1 Robert G W Kirk A1 Reuben Message A1 Dmitriy Myelnikov A1 Alexandra Palmer A1 Emma Roe A1 Vanessa Ashall A1 Bentley Crudgington A1 Renelle McGlacken A1 Sara Peres A1 Tess Skidmore YR 2020 UL http://mh.bmj.com/content/46/4/499.abstract AB Animals used in biological research and testing have become integrated into the trajectories of modern biomedicine, generating increased expectations for and connections between human and animal health. Animal research also remains controversial and its acceptability is contingent on a complex network of relations and assurances across science and society, which are both formally constituted through law and informal or assumed. In this paper, we propose these entanglements can be studied through an approach that understands animal research as a nexus spanning the domains of science, health and animal welfare. We introduce this argument through, first, outlining some key challenges in UK debates around animal research, and second, reviewing the way nexus concepts have been used to connect issues in environmental research. Third, we explore how existing social sciences and humanities scholarship on animal research tends to focus on different aspects of the connections between scientific research, human health and animal welfare, which we suggest can be combined in a nexus approach. In the fourth section, we introduce our collaborative research on the animal research nexus, indicating how this approach can be used to study the history, governance and changing sensibilities around UK laboratory animal research. We suggest the attention to complex connections in nexus approaches can be enriched through conversations with the social sciences and medical humanities in ways that deepen appreciation of the importance of path-dependency and contingency, inclusion and exclusion in governance and the affective dimension to research. In conclusion, we reflect on the value of nexus thinking for developing research that is interdisciplinary, interactive and reflexive in understanding how accounts of the histories and current relations of animal research have significant implications for how scientific practices, policy debates and broad social contracts around animal research are being remade today.